Research
Sunnybrook Health Sciences Centre, Toronto
Mount Sinai Hospital, Toronto
The Hospital for Sick Children, Toronto
- Diagnosis, management and outcomes of preterm infants with acute and chronic pulmonary hypertension
- Right ventricle in pulmonary hypertensive crisis in neonates
- Acute care physiology in relation to late-onset sepsis in the NICU
- Non-invasive cardiac output monitoring in preterm neonates
- Transitional hypotension in microprems
- Pharmacological and surgical management of patent ductus arteriosus
- Neurohemodynamic monitoring and its relevance in extreme preterm infants
- Flow vorticity, energy losses and intraventricular pressure gradient in the transitional period studied by blood speckle imaging
- Validation of echocardiographic measures of pulmonary hypertension in neonates
BC Women’s Hospital, Vancouver
- Myocardial dysfunction and hemodynamic changes in septic shock
- Cerebral perfusion changes & adverse respiratory outcomes after patent ductus arteriosus ligation
- Cardiovascular adaptation in preterm neonates with and without fetal growth restriction
- Echocardiographic predictors of adverse clinical outcomes in infants with congenital diaphragmatic hernia
Stollery Children’s Hospital (Royal Alexandra Hospital Site), Edmonton
- Multimodal monitoring of hemodynamics in extremely low birth weight preterm infants in a Canadian tertiary level unit - Non-Blinded RCT( MUSE Trial)
- ZEST (Zonal Edmonton consultation Service of TNE)
- The Value of Early Echocardiographic Parameters to Predict Chronic Pulmonary Hypertension in Extreme Premature Infants
- Attitudes and Perceptions toward Nurse Practitioner performed Targeted Neonatal Echocardiography in a tertiary neonatal intensive care unit
Health Sciences Centre Winnipeg – Women’s Hospital and NICU, Winnipeg
- Early identification of preterm infants with evolving Bronchopulmonary dysplasia: utility of Lung Ultrasound severity score
- Multicenter randomized control trial of using sildenafil versus nitric oxide for infants with congenital diaphragmatic hernia
- A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge
- Changes in neonatal hemodynamics with different ventilation modalities.
- The effect of two different modes of Noninvasive Ventilation on Regional Cerebral and Splanchnic blood flow as measured by Noninvasive Near Infrared Spectroscopy (NIRS) and Echocardiography and Doppler ultrasound in the extremely premature newborn infant.
- Use of serial Doppler ultrasound to Predict Improvement of Mesenteric Blood Flow in Preterm Infants with Necrotizing Enterocolitis.
- Necrotizing enterocolitis after RBC transfusion in preterm infants with PDA, a retrospective study.
- Lung ultrasound in infants requiring respiratory support
London Health Sciences Centre, London
- Cardiac Effects of Post Natal Steroid Use
- Left Atrial Speckle Tracking in Premature Neonates
- Educational Impact of Targeted Neonatal Echocardiography
- Feasibility and Utility of Early Cardiac and Cerebral Function Monitoring in Premature Neonates
- Combination therapy with Acetaminophen and Ibuprofen In Neonates with Patent Ductus Arteriosus. Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit (MUSE trial)
- Pulmonary Artery dopplers for early prediction of risk for Bronchopulmonary Dysplasia in Extremely Low Birth Weight babies
- The value of early echocardiographic parameters to predict Broncho pulmonaryDysplasia associated chronic pulmonary hypertension (BPD-PH) in extreme prematureinfants
- Incorporating echocardiographic and biochemical markers in BPD predictive model for preterm neonate
- ZEST (Zonal Edmonton consultation Service of TNE) project
Montreal Children’s Hospital – McGill University Health Centre, Montréal
Information regarding Dr. Altit's Research Program entitled Neonatal Outcomes Related to the early Discovery of Impaired Cardiac function (NORDIC) can be found on the NeoCardio Lab Website.
CHU de Québec-Université Laval, Quebec City
- Pulmonary vascular disease and cardiac performance in extreme preterm infants
- Comparison of prevalence in chronic pulmonary hypertension in BPD and association with approach to PDA management
- Management of Chronic Pulmonary Hypertension in BPD: Perspectives of Neonatologists vs. Pediatric Cardiologists
- Dose-response and treatment effectiveness in HsPDA through echocardiography assessment
IWK Health Centre, Halifax
- Milking of the Cut Cord during Resuscitation of Preterm Infants: A randomized controlled study (The MOCC Study)
- Relative effectiveness and safety of pharmacotherapeutic agents for treatment of patent ductus arteriosus (PDA) in preterm infants: A National Comparative Effectiveness Research (CER) Project (Canadian National PDA Treatment Study)
- Effect of Common Neonatal Intensive Care Unit medications on cerebral perfusion and hemodynamics of preterm infants (The Hemodynamics, Perfusion & Oxygenation in preterms, HiPpO study)
- Effect of Routine Caregiving Interventions on Cerebral Perfusion & Oxygenation in Very Preterm Infants (The NeoCOP study)
- Impact of Implementing Point of Care Lung Ultrasound Program in the Neonatal Intensive Care Unit
Foothills Medical Centre, Calgary
- Assessment of Right ventricular function in preterm infants
- The Effect of Surfactant Administration on Cerebral Tissue Oxygenation and Hemodynamics in Preterm Infants <29 weeks of Gestation. A Pilot Prospective Cohort Study
- Echocardiographic predictors of adverse clinical outcomes in infants with Congenital Diaphragmatic Hernia
- Estimation of umbilical venous catheter insertion length using echocardiography
Children’s Hospital of Eastern Ontario (CHEO), Ottawa
- Effect of different doses of Ibuprofen on cerebral and splanchnic tissue oxygenation during treatment of patent ductus arteriosus (PDA) in preterm infants: An observational study
Giesinger Hemodynamics Program at University of Iowa, Iowa City
- Early TNE evaluation of Ultra-Low Birth Weight Infants during the Transitional Period and Physiology Guided Management
- Hemodynamic Effects of Late Surfactant in ELBW infants
- Early Prediction of PDA in ELBW infants
- Retinopathy of Prematurity and PDA
- Impact of Hemodynamic Consultation in US NICU
- Impact of Early PDA screening on care of babies less than 27 weeks’ gestation
- Predictive analytics in prevention of morbidities in ELBW infants
- Right Ventricular Function and Hypoxic-Ischemic Encephalopathy
- Right ventricular function in the setting of Congenital Diaphragmatic Hernia
- Nitric Oxide Responsiveness and myocardial function in acute Pulmonary Hypertension
- Role of Echocardiography simulator in neonatal training
- Role of inhaled epoprostenol in pulmonary vascular disease and chronic pulmonary hypertension
Boston Children’s Hospital, Boston
- Assessment of right ventricle-pulmonary vascular coupling physiology and importance in acquired and congenital heart disease
- Acute care physiology in relation to necrotizing enterocolitis in the neonatal and cardiac intensive care units
- Management of hemodynamic compromise in neonates suffering from hypoxic ischemic encephalopathy
Sharp Mary Birch NRI, San Diego
- Comparing cord milking to early cord clamping in term non-vigorous infants (MINVI trial).
- Comparing delayed cord clamping to umbilical cord milking in preterm infants (PREMOD2 trial).
- Comparing empiric antibiotic therapy to placebo in extremely low birthweight infants (NANO trial).
- Comparing early CPAP to early minimal invasive surfactant administration (LISA) in preterm infants.
- Evaluating the use of Sodium Cromolyn therapy in preterm infants to reduce BPD,
- Comparing the effectiveness of nasal high flow cannula to CPAP using Electrical Impedance Tomography.
Children’s Hospital of Orange County, Orange County
- Normative Echocardiographic Values for Right and Left Ventricular Function in Extremely Premature Neonates
Nationwide Children’s Hospital, Columbus
- Early prediction of spontaneous patent ductus arteriosus closure and PDA-associated outcomes
- Impact of gestational age and perinatal factors on cardiac function in extremely preterm infants
- The role of milrinone in neonates with persistent pulmonary hypertension unresponsive to inhaled nitric oxide
- Prediction of inhaled nitric oxide responsiveness in pulmonary hypertension
- Patent Ductus Arteriosus Closure and PDA-Associated Outcomes
- Regulation of PDE3 in the Pathobiology of Pulmonary Hypertension
- PIVOTAL: Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants
Children’s Hospital at Oklahoma University Health Science Center, Oklahoma
- Racial disparities in development of chronic pulmonary hypertension
- Differential mi-RNA expression in VLBWs with and without Pulmonary hypertension from Birth to discharge
Lucile Packard Children’s Hospital Stanford, Palo Alto
- Targeted brain oxygenation
- Impact of echocardiographic measures of pulmonary hypertension, shunting patterns, and ventricular dysfunction on the outcome of
- Milrinone in CDH trial
University of Rochester Medical Center-Golisano Children's Hospital (GCH)
- Safety, preliminary effectiveness and pharmacokinetics of Sildenafil in premature infants at risk of BPD
- NICHD Neonatal Research Network trials: Management of PDA and Milrinone in CHD
Children’s Hospital of Philadelphia, Philadelphia
- Milrinone in Congenital diaphragmatic Hernia. NICHD Neonatal Research Network (PI: María Victoria Fraga , MD)
- Nitric Oxide responsivity in infants with Severe Chronic Lung Disease (PI: María Victoria Fraga, MD)
- Point-of-care ultrasound for evaluation of ECMO cannula position in neonates (Lead: Thomas Pawlowski, MD)
Columbia University Neonatal Hemodynamics Program, New York
- Participating site in the Preliminary Percutaneous intervention versus Observational Trial of Arterial Ductus in Low-weight Infants (PIVOTAL)
- Participating site in the VentFirst Study
- Founding member of the Delivery Room Intervention and Evaluation (DRIVE) Network
- Patent Ductus Arteriosus Assessment with Objective Measures
Liverpool Women’s Hospital in Liverpool, UK
- Baby OSCAR Trial
- RePHiNe- International Neonatal Pulmonary Hypertension Registry
- A comparison of two iNO dosing regimens
Royal Hospital for Children, Glasgow, Scotland
- Application of advanced functional echocardiography in neonatal disease
- Cardiac dysfunction and pulmonary hypertension in congenital diaphragmatic hernia
- Assessment and management of patent ductus arteriosus
- Multi-modal haemodynamic assessment to guide targeted management in term and preterm
- Optimal management of the umbilical cord, with bedside stabilisation, in preterm infant and relationship to haemodynamic transition
- The impact of cerebral NIRS on perinatal management of extremely preterm infants
La Paz University Hospital, Madrid, Spain
- Randomized double blind multicenter phase III clinical trial for evaluating two strategies for treating ductus arteriosus echocardiographically guided with ibuprofen: impact on the bowel prognosis
- SafeBoosC III (Safeguarding the brain of our smallest children)
- Neoflow (systemic flow assessed with NPE during transitional circulation)
- Online cerebral pressure autoregulation continuous monitoring as a neurobiomarker to guide assessment and intervention to prevent or minimize brain injury in the high-risk preterm infant
- NEO-CIRC-003. An International multicenter randomized placebo-controlled, double blind three arm trial to investigate the efficacy of dobutamine with two different starting doses in the treatment of haemodynamic insufficiency in the immediate postnatal period.
Radboudumc Amalia Children’s Hospital, Nijmegen, the Netherlands
- EDSCINI Study (Early Detection of Shock in Critically Ill Newborn Infants)
- BeNeDuctus Trial (International multi-centre,randomised non-inferiority trial of early treatment versus expectative management of patent ductus arteriosus in preterm infants).
- Companion (Comprehensive haemodynamic monitoring of the newborn)
Santa Maria della Misericordia Hospital, Udine, Italy
- Lungs and heart interaction in preterm infants with chronic lung disease: the ultrasound perspective
- Application of advanced functional echocardiography in preterm infants with chronic lung disease
- Measure of non-invasive marker of pulmonary function in preterm infants with chronic lung disease
Careggi University Hospital, Florence, Italy
- Atrial strain as normal value and in pathological conditions
- Interaction between hemodynamics and lung ultrasound score
Azienda Ospedaliera Universitaria Integrata Verona, Italy
- Atrial deformation in the neonate: a mirror of ventricular function? (PI: Benjamim Ficial)
- Ultrasound SVC flow quantification: validation of a modified technique (PI: Benjamim Ficial)
- Atrial function in neonates with TTN: a prospective observational case-control study (PI: Benjamim Ficial)
- SVC flow and blood flow volume in extracerebral arteries (PI: Benjamim Ficial)
Saint Mary’s Hospital, Manchester, UK
- Paracetamol and Ibuprofen Research Pilot trial (PAIR) – Dr. Arin Mukherjee (CI)
- WHEAT Trial – Blood Transfusion during feeding - Dr. Ruth Gottstein (PI)
- DOLFIN- HIE - Dr. Aparajita Basu (PI)
- FOOTPRINTS – biomarkers for CLD
- NEOGASTIC – Measuring routine gastric residuals – Dr. Tom Hogan (PI)
The newborn services at Manchester have a dedicated research unit led by research lead Dr. Mukherjee, consultant neonatologist. Several portfolio studies are undertaken like SURFON study, ALLIANCE study, NEOVANC Study, Cool cuddle 2 study etc. The following studies are ongoing:
Cork, Ireland
- There are two multicentre randomised controlled trials ongoing within the neonatal unit evaluating different interventions for management of the PDA. These are Treocapa and ETAPA.
- Two observational studies are ongoing addressing transition in the delivery room and the second evaluating BPD associated PH.
Sidra Medicine, Doha, Qatar
- Effects of packed red blood cell Transfusion on Hemodynamics and tissue OxygenationS in preterm infants (ETHOS) study
- Utilizing Precision Medicine (Single-cell RNA Sequencing and Advance Hemodynamic Monitoring) Approach to Predict the Outcome in Late Onset Neonatal Sepsis?
- U-Premier Study for Neonatal Sepsis
- Art of Precision Medicine (Whole Genome, Transcriptome, Methylome, Metabolome, and Advance Hemodynamic Monitoring) for Early Prediction of Outcome in Neonatal Congenital Diaphragmatic Hernia, APPLLE study for CDH
- Sidra Institutional Research Fund (IRF)
- Qatar National Research Fund (QNRF)
John Hunter Children’s Hospital
- Cardiac remodeling after preterm birth: Exploring the pathophysiology behind changes in cardiac shape and size after preterm birth.
- Intracardiac blood flow studies: using blood speckle imaging to help understand myocardial function and energetics.
- Left ventricular diastolic function in preterm infants: clinical and echocardiography studies to help detail diastolic function.
- Sepsis and septic shock: understanding hemodynamics and ultrasound methods to guide treatments.
Monash Children’s Hospital
Main areas of research: Perinatal transition, fetal growth restriction, bronchopulmonary dysplasia, Cardiac remodelling and adaptation after severe fetal growth restriction, PLUSS Echo trial.
Royal Hospital for Women
- Novel ultrasound quantification techniques for evaluating organ perfusion
- Application of four-dimensional ultrasound techniques in newborn care
Royal Prince Alfred Hospital
- RPA has an extensive history of neonatal haemodynamic research with numerous publications from the department including research correlating TNE findings to clinical outcomes as well as randomised controlled trials.
- Current Neonatal haemodynamic research is focused on outcomes of infants born prematurely using aortic intima-media thickness.
The Grace Centre for Newborn Intensive Care (The Children’s Hospital at Westmead)
- Hemodynamics in congenital diaphragmatic hernia
- NIRTURE Study: A multicentre randomised controlled trial in premature babies (<29 weeks gestation at birth). Research question: Can using a dedicated treatment using cerebral oxygenation monitoring (NIRs) compared to usual treatment reduce the burden of cerebral hypoxia and hyperoxia in the first 5 days? Chief Investigator: Dr Himanshu Popat.
- Acute pulmonary hypertension in term and preterm neonates
- Hemodynamic management of neonates referred for ECMO
- Hemodynamics and outcomes following surgical PDA closure (ligation and transcatheter closure)
Royal Women’s Hospital (Melbourne), Victoria, Australia
The Royal Women’s Hospital Melbourne is involved in lung and cardiac research. Currently a participating site for the PLUSS Trial (Preventing Lung Disease Using Surfactant + Steroid) looking at PDA assessment and treatment after intratracheal steroid and surfactant. Ongoing research utilising Lung USS for extubation and lung recruitment.
Dr. Amish Jain
Dr. Poorva Deshpande
Dr. Dany Weisz
Dr. Luc Mertens
Dr. Souvik Mitra
Dr. Soume Bhattacharya
Dr. Gabriel Altit
Dr. Audrey Hebert and Dr. Christine Drolet
Dr.Nadya Ben Fadel and Dr. Robert Jankov
Dr. Patrick McNamara, Dr. Danielle R. Rios, Dr. Regan Giesinger, and Dr. Sarah Haskell
Dr. Leeann Pavlek
Dr. Marjorie Makoni
Dr. Shazia Bhombal
Dr. Neil Patel
Dr. Anne Marie Heuchan
Dr. Willem P. de Boode
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The current NHTS executive committee includes neonatologists with hemodynamics expertise, pediatric cardiologists with an interest in neonatal health and pediatrics sonographers.
LATEST CASE
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Case Report 7: A case of neonatal dilated cardiomyopathy and congenital hydrocephalus
Month: 11/2022
Authors: Laura Wilson, Catalina Bazacliu and J. Lauren Ruoss (Divisions of Neonatology & Cardiology, University of Florida Gainesville & Division of Neonatology, Orlando Health Regional Medical Center)