Information regarding Dr. Altit's Research Program entitled Neonatal Outcomes Related to the early Discovery of Impaired Cardiac function (NORDIC) can be found on the NeoCardio Lab Website.
The newborn services at Manchester have a dedicated research unit led by research lead Dr. Mukherjee, consultant neonatologist. Several portfolio studies are undertaken like SURFON study, ALLIANCE study, NEOVANC Study, Cool cuddle 2 study etc. The following studies are ongoing:
Main areas of research: Perinatal transition, fetal growth restriction, bronchopulmonary dysplasia, Cardiac remodelling and adaptation after severe fetal growth restriction, PLUSS Echo trial.
The Royal Women’s Hospital Melbourne is involved in lung and cardiac research. Currently a participating site for the PLUSS Trial (Preventing Lung Disease Using Surfactant + Steroid) looking at PDA assessment and treatment after intratracheal steroid and surfactant. Ongoing research utilising Lung USS for extubation and lung recruitment.
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The Neonatal Hemodynamics Research Center wishes to acknowledge the uniquely brilliant career of Dr Regan Giesinger. Regan completed her training in neonatal-perinatal medicine and neonatal hemodynamics at the University of Toronto. She was appointed as Assistant Professor of Pediatrics and Staff Neonatologist at SickKids hospital, Toronto in 2015. Thereafter, she was appointed Director of one of the world’s leading neonatal hemodynamics programs and Associate Professor of Pediatrics at the University of Iowa in 2018. Although quiet and humble in every encounter, Regan’s intelligence and quick thinking intimidated many. She recognized that if we are to provide the “best” care, there was an urgent need to re-engage with physiology and in providing the “right” therapy, clinicians needed to recognize the importance of diagnostic precision and delineation of the specific phenotype. Regan’s dedication to patients and their families was second to none.
Regan was an exceptional young clinician scientist, who at a very early stage of her career, achieved an international reputation in her chosen field of neonatal hemodynamics and the application of targeted neonatal echocardiography (TNE) as a critical bedside tool to enhance clinical care and research through the provision of enhanced diagnostic and mechanistic insights. Although her career was cut short, she made substantial scientific contributions including 65 original articles, 11 book chapters, and numerous abstracts. She also served as a co-investigator on several National Institute of Health (NIH) grants. Her primary research work, which characterized the relationship between right ventricular dysfunction and neurodevelopmental outcomes in term neonates with hypoxic ischemic encephalopathy, was precedent setting and has laid the foundation for further investigations aimed at improving the outcomes for this vulnerable population of neonates. She also published several original contributions related to novel therapies in pulmonary hypertension, and the use of nitric oxide in preterm infants. In addition, she delivered more than 100 invited talks across the world, including the United States, Canada, Sweden, Romania, Italy, India, and the UK. She was honored with delivering the 2020 Neonatal Hemodynamics club lecture at PAS. Regan showed outstanding strength, integrity and leadership in education, training and administrative roles, and represented the very best of academic medicine. She was a member of the Neonatal Hemodynamics Advisory at PAS and was an executive member of the Neonatal Hemodynamics and TNE specialty interest group at the American Society of Echocardiography. In 2021, Regan was appointed as fellow of the American Society of Echocardiography (FASE), making her one of the few neonatologists to receive this accolade.
I would say her greatest achievement has been re-shaping the minds of so many young trainees and building the culture of the hemodynamics movement in Neonatology. Regan was a deep thinker, and time spent reflecting on complex patients, gaps in scientific knowledge or debating optimal hemodynamic care was when she flourished. Her landmark publication in the Blue Journal on the beneficial impact of hemodynamic screening on outcomes in extremely preterm babies is transformative. Sadly, Regan passed away from us after an extensive battle with cancer on May 16th, 2023. She has left behind a powerful legacy. In teaching the importance of physiology and diagnostic precision in cardiovascular care, Regan has influenced a generation of trainees and young faculty. Her contributions in the field of neonatal hemodynamics will continue to guide us for years to come.
Dr. Patrick J McNamara
On behalf of the Neonatal Hemodynamics Program, University of Iowa and
Neonatal Hemodynamics Research Centre
NPA: Dr. Amish Jain
Funding: Heart & Stroke Ontario Clinician Scientist (Phase II) Award
The focus of the IMPRINT research program is to improve the clinical care and reduce the burden of pulmonary heart disease in preterm neonates suffering from pulmonary hypertension. The program’s current studies are:
Prospective observational study to develop robust echocardiographic criteria for early identification of preterm infants at risk of developing chronic pulmonary hypertension PMID: 33789855 | DOI: 10.1136/bmjopen-2020-044924
Funding: Canadian Institutes of Health Research (IHDCYH)–SickKids Foundation Participating sites: 6 NHRC sites across Canada, the United States & Europe
A detailed registry of preterm neonates treated with inhaled nitric oxide Funding: Mallinckrodt Investigator Initiated Research Grant Participating sites: 12 Canadian NHRC sites
NPA: Dr. Dany Weisz
PA: Dr. Amish Jain, Dr. Luc Mertens, Dr. Prakesh Shah
The main objective of this study is to develop an outcome-based definition of ‘significant’ PDA among extremely low gestational age neonates at different postnatal ages. Funding: Canadian Institutes of Health Research Project Grant Participating sites: 17 Canadian NHRC sites
NPA: Dr. Souvik Mitra
PA: Dr. Amish Jain, Dr. Prakesh Shah
The main objective of this registry-based comparative effectiveness research study is to compare the different pharmacotherapeutic practices aimed at closure of patent ductus arteriosus and to evaluate their impact on clinical outcomes in extremely preterm infants (<29 weeks GA) . Funding: Canadian Institutes of Health Research Project Grant Participating sites: 22 Canadian sites
NPA: Dr. Joseph Ting
Participating sites: BC Women’s Hospital and Health Centre & University of Iowa Stead Family Children’s Hospital
NPA: Audrey Hebert
Participating sites: CHU de Québec-Université Laval & University of Iowa Stead Family Children’s Hospital
Click here to read!
Case Report 7: A case of neonatal dilated cardiomyopathy and congenital hydrocephalus
Authors: Laura Wilson, Catalina Bazacliu and J. Lauren Ruoss (Divisions of Neonatology & Cardiology, University of Florida Gainesville & Division of Neonatology, Orlando Health Regional Medical Center)