Neonatal Hemodynamics | Research Centre

Research

An up-to-date list of current academic endeavours being pursued at participating sites. (Last updated: March 10, 2023)

Sunnybrook Health Sciences Centre, Toronto
Mount Sinai Hospital, Toronto
The Hospital for Sick Children, Toronto

Diagnosis, management and outcomes of preterm infants with acute and chronic pulmonary hypertension
Right ventricle in pulmonary hypertensive crisis in neonates
Acute care physiology in relation to late-onset sepsis in the NICU
Non-invasive cardiac output monitoring in preterm neonates
Transitional hypotension in microprems
Pharmacological and surgical management of patent ductus arteriosus
Neurohemodynamic monitoring and its relevance in extreme preterm infants
Flow vorticity, energy losses and intraventricular pressure gradient in the transitional period studied by blood speckle imaging
Validation of echocardiographic measures of pulmonary hypertension in neonates

BC Women’s Hospital, Vancouver

Myocardial dysfunction and hemodynamic changes in septic shock
Cerebral perfusion changes & adverse respiratory outcomes after patent ductus arteriosus ligation
Cardiovascular adaptation in preterm neonates with and without fetal growth restriction
Echocardiographic predictors of adverse clinical outcomes in infants with congenital diaphragmatic hernia

Stollery Children’s Hospital (Royal Alexandra Hospital Site), Edmonton

Multimodal monitoring of hemodynamics in extremely low birth weight preterm infants in a Canadian tertiary level unit - Non-Blinded RCT( MUSE Trial)
ZEST (Zonal Edmonton consultation Service of TNE)
The Value of Early Echocardiographic Parameters to Predict Chronic Pulmonary Hypertension in Extreme Premature Infants
Attitudes and Perceptions toward Nurse Practitioner performed Targeted Neonatal Echocardiography in a tertiary neonatal intensive care unit

Health Sciences Centre Winnipeg – Women’s Hospital and NICU, Winnipeg

Early identification of preterm infants with evolving Bronchopulmonary dysplasia: utility of Lung Ultrasound severity score
Multicenter randomized control trial of using sildenafil versus nitric oxide for infants with congenital diaphragmatic hernia
A Patent Ductus Arteriosus Severity Score Predicts Chronic Lung Disease or Death before Discharge
Changes in neonatal hemodynamics with different ventilation modalities.
The effect of two different modes of Noninvasive Ventilation on Regional Cerebral and Splanchnic blood flow as measured by Noninvasive Near Infrared Spectroscopy (NIRS) and Echocardiography and Doppler ultrasound in the extremely premature newborn infant.
Use of serial Doppler ultrasound to Predict Improvement of Mesenteric Blood Flow in Preterm Infants with Necrotizing Enterocolitis.
Necrotizing enterocolitis after RBC transfusion in preterm infants with PDA, a retrospective study.
Lung ultrasound in infants requiring respiratory support

London Health Sciences Centre, London

Cardiac Effects of Post Natal Steroid Use
Left Atrial Speckle Tracking in Premature Neonates
Educational Impact of Targeted Neonatal Echocardiography
Feasibility and Utility of Early Cardiac and Cerebral Function Monitoring in Premature Neonates
Combination therapy with Acetaminophen and Ibuprofen In Neonates with Patent Ductus Arteriosus. Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit (MUSE trial)
Pulmonary Artery dopplers for early prediction of risk for Bronchopulmonary Dysplasia in Extremely Low Birth Weight babies
The value of early echocardiographic parameters to predict Broncho pulmonaryDysplasia associated chronic pulmonary hypertension (BPD-PH) in extreme prematureinfants
Incorporating echocardiographic and biochemical markers in BPD predictive model for preterm neonate
ZEST (Zonal Edmonton consultation Service of TNE) project

Montreal Children’s Hospital – McGill University Health Centre, Montréal

Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study
“ECHO-CDH – Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia”
Do cerebral and renal saturations measured with near-infrared spectroscopy correlate with echocardiographic markers of perfusion and cardiac performance in congenital heart disease?

CHU de Québec-Université Laval, Quebec City

Pulmonary vascular disease and cardiac performance in extreme preterm infants
Comparison of prevalence in chronic pulmonary hypertension in BPD and association with approach to PDA management
Management of Chronic Pulmonary Hypertension in BPD: Perspectives of Neonatologists vs. Pediatric Cardiologists
Dose-response and treatment effectiveness in HsPDA through echocardiography assessment

IWK Health Centre, Halifax

Milking of the Cut Cord during Resuscitation of Preterm Infants: A randomized controlled study (The MOCC Study)
Relative effectiveness and safety of pharmacotherapeutic agents for treatment of patent ductus arteriosus (PDA) in preterm infants: A National Comparative Effectiveness Research (CER) Project (Canadian National PDA Treatment Study)
Effect of Common Neonatal Intensive Care Unit medications on cerebral perfusion and hemodynamics of preterm infants (The Hemodynamics, Perfusion & Oxygenation in preterms, HiPpO study)
Effect of Routine Caregiving Interventions on Cerebral Perfusion & Oxygenation in Very Preterm Infants (The NeoCOP study)
Impact of Implementing Point of Care Lung Ultrasound Program in the Neonatal Intensive Care Unit

Foothills Medical Centre, Calgary

Assessment of Right ventricular function in preterm infants
The Effect of Surfactant Administration on Cerebral Tissue Oxygenation and Hemodynamics in Preterm Infants <29 weeks of Gestation. A Pilot Prospective Cohort Study
Echocardiographic predictors of adverse clinical outcomes in infants with Congenital Diaphragmatic Hernia
Estimation of umbilical venous catheter insertion length using echocardiography

Children’s Hospital of Eastern Ontario (CHEO), Ottawa

Effect of different doses of Ibuprofen on cerebral and splanchnic tissue oxygenation during treatment of patent ductus arteriosus (PDA) in preterm infants: An observational study

Giesinger Hemodynamics Program at University of Iowa, Iowa City

Early TNE evaluation of Ultra-Low Birth Weight Infants during the Transitional Period and Physiology Guided Management
Hemodynamic Effects of Late Surfactant in ELBW infants
Early Prediction of PDA in ELBW infants
Retinopathy of Prematurity and PDA
Impact of Hemodynamic Consultation in US NICU
Impact of Early PDA screening on care of babies less than 27 weeks’ gestation
Predictive analytics in prevention of morbidities in ELBW infants
Right Ventricular Function and Hypoxic-Ischemic Encephalopathy
Right ventricular function in the setting of Congenital Diaphragmatic Hernia
Nitric Oxide Responsiveness and myocardial function in acute Pulmonary Hypertension
Role of Echocardiography simulator in neonatal training
Role of inhaled epoprostenol in pulmonary vascular disease and chronic pulmonary hypertension

Boston Children’s Hospital, Boston

Assessment of right ventricle-pulmonary vascular coupling physiology and importance in acquired and congenital heart disease
Acute care physiology in relation to necrotizing enterocolitis in the neonatal and cardiac intensive care units
Management of hemodynamic compromise in neonates suffering from hypoxic ischemic encephalopathy

Sharp Mary Birch NRI, San Diego

Comparing cord milking to early cord clamping in term non-vigorous infants (MINVI trial).
Comparing delayed cord clamping to umbilical cord milking in preterm infants (PREMOD2 trial).
Comparing empiric antibiotic therapy to placebo in extremely low birthweight infants (NANO trial).
Comparing early CPAP to early minimal invasive surfactant administration (LISA) in preterm infants.
Evaluating the use of Sodium Cromolyn therapy in preterm infants to reduce BPD,
Comparing the effectiveness of nasal high flow cannula to CPAP using Electrical Impedance Tomography.

Children’s Hospital of Orange County, Orange County

Normative Echocardiographic Values for Right and Left Ventricular Function in Extremely Premature Neonates

Nationwide Children’s Hospital, Columbus

Early prediction of spontaneous patent ductus arteriosus closure and PDA-associated outcomes
Impact of gestational age and perinatal factors on cardiac function in extremely preterm infants
The role of milrinone in neonates with persistent pulmonary hypertension unresponsive to inhaled nitric oxide
Prediction of inhaled nitric oxide responsiveness in pulmonary hypertension
Patent Ductus Arteriosus Closure and PDA-Associated Outcomes
Regulation of PDE3 in the Pathobiology of Pulmonary Hypertension
PIVOTAL: Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

Children’s Hospital at Oklahoma University Health Science Center, Oklahoma

Racial disparities in development of chronic pulmonary hypertension
Differential mi-RNA expression in VLBWs with and without Pulmonary hypertension from Birth to discharge

Lucile Packard Children’s Hospital Stanford, Palo Alto

Targeted brain oxygenation
Impact of echocardiographic measures of pulmonary hypertension, shunting patterns, and ventricular dysfunction on the outcome of
Milrinone in CDH trial

University of Rochester Medical Center-Golisano Children's Hospital (GCH)

Safety, preliminary effectiveness and pharmacokinetics of Sildenafil in premature infants at risk of BPD
NICHD Neonatal Research Network trials: Management of PDA and Milrinone in CHD

Children’s Hospital of Philadelphia, Philadelphia

Milrinone in Congenital diaphragmatic Hernia. NICHD Neonatal Research Network (PI: María Victoria Fraga , MD)
Nitric Oxide responsivity in infants with Severe Chronic Lung Disease (PI: María Victoria Fraga, MD)
Point-of-care ultrasound for evaluation of ECMO cannula position in neonates (Lead: Thomas Pawlowski, MD)

The Rotunda Hospital, Dublin

Early targeted treatment of PDA in high risk preterm infants based on a risk severity score
Pulmonary hemodynamics and cardiac function in children with trisomy 21
Adjunctive role of milrinone in management of pulmonary hypertension in term and near term infants
Role of deformation imaging in delineating cardiovascular phenotype in neonatal disease states
Impact of gestational age and neonatal morbidities on cardiovascular development in premature infants

Liverpool Women’s Hospital in Liverpool, UK

UK Baby OSCAR Trial
Examining the natural history of chronic pulmonary hypertension in neonates

Royal Hospital for Children, Glasgow, Scotland

Application of advanced functional echocardiography in neonatal disease
Cardiac dysfunction and pulmonary hypertension in congenital diaphragmatic hernia
Assessment and management of patent ductus arteriosus
Multi-modal haemodynamic assessment to guide targeted management in term and preterm
Optimal management of the umbilical cord, with bedside stabilisation, in preterm infant and relationship to haemodynamic transition
The impact of cerebral NIRS on perinatal management of extremely preterm infants

La Paz University Hospital, Madrid, Spain

Randomized double blind multicenter phase III clinical trial for evaluating two strategies for treating ductus arteriosus echocardiographically guided with ibuprofen: impact on the bowel prognosis
SafeBoosC III (Safeguarding the brain of our smallest children)
Neoflow (systemic flow assessed with NPE during transitional circulation)
Online cerebral pressure autoregulation continuous monitoring as a neurobiomarker to guide assessment and intervention to prevent or minimize brain injury in the high-risk preterm infant
NEO-CIRC-003. An International multicenter randomized placebo-controlled, double blind three arm trial to investigate the efficacy of dobutamine with two different starting doses in the treatment of haemodynamic insufficiency in the immediate postnatal period.

Radboudumc Amalia Children’s Hospital, Nijmegen, the Netherlands

EDSCINI Study (Early Detection of Shock in Critically Ill Newborn Infants)
BeNeDuctus Trial (International multi-centre,randomised non-inferiority trial of early treatment versus expectative management of patent ductus arteriosus in preterm infants).
Companion (Comprehensive haemodynamic monitoring of the newborn)

Santa Maria della Misericordia Hospital, Udine, Italy

Lungs and heart interaction in preterm infants with chronic lung disease: the ultrasound perspective
Application of advanced functional echocardiography in preterm infants with chronic lung disease
Measure of non-invasive marker of pulmonary function in preterm infants with chronic lung disease

Careggi University Hospital, Florence, Italy

Atrial strain as normal value and in pathological conditions
Interaction between hemodynamics and lung ultrasound score

Azienda Ospedaliera Universitaria Integrata Verona, Italy

Atrial deformation in the neonate: a mirror of ventricular function? (PI: Benjamim Ficial)
Ultrasound SVC flow quantification: validation of a modified technique (PI: Benjamim Ficial)
Atrial function in neonates with TTN: a prospective observational case-control study (PI: Benjamim Ficial)
SVC flow and blood flow volume in extracerebral arteries (PI: Benjamim Ficial)

An up-to-date list of current academic endeavours being pursued at participating sites.